Rod photoreceptor clearance due to misfolded rhodopsin is linked to a DAMP-immune checkpoint switch

Chronic endoplasmic reticulum stress resulting from misfolding of the visual pigment rhodopsin (RHO) can lead to loss of rod photoreceptors, which initiates retinitis pigmentosa, characterized initially by diminished nighttime and peripheral vision. Cone photoreceptors depend on rods for glucose tra...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Lee, Sang Joon, Wang, Wei, Jin, Lei, Lu, Xiaoqin, Gao, Lei, Chen, Yao, Liu, Tingting, Emery, Douglas, Vukmanic, Eric, Liu, Yongqing, Kaplan, Henry J., Dean, Douglas C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949052/
https://ncbi.nlm.nih.gov/pubmed/33214223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016053
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