Rod photoreceptor clearance due to misfolded rhodopsin is linked to a DAMP-immune checkpoint switch

Chronic endoplasmic reticulum stress resulting from misfolding of the visual pigment rhodopsin (RHO) can lead to loss of rod photoreceptors, which initiates retinitis pigmentosa, characterized initially by diminished nighttime and peripheral vision. Cone photoreceptors depend on rods for glucose tra...

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Foilsithe in:J Biol Chem
Main Authors: Lee, Sang Joon, Wang, Wei, Jin, Lei, Lu, Xiaoqin, Gao, Lei, Chen, Yao, Liu, Tingting, Emery, Douglas, Vukmanic, Eric, Liu, Yongqing, Kaplan, Henry J., Dean, Douglas C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2020
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949052/
https://ncbi.nlm.nih.gov/pubmed/33214223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016053
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