Pharmacological clearance of misfolded rhodopsin for the treatment of RHO-associated retinitis pigmentosa.

Rhodopsin mutation and misfolding is a common cause of autosomal dominant retinitis pigmentosa. Using a luciferase reporter assay, we undertook a small-molecule high-throughput screening of 68,979 compounds and identified nine compounds that selectively reduced the misfolded P23H rhodopsin without a...

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Veröffentlicht in:FASEB J
Hauptverfasser: Liu, Xujie, Feng, Bing, Vats, Abhishek, Tang, Hong, Seibel, William, Swaroop, Manju, Tawa, Gregory, Zheng, Wei, Byrne, Leah, Schurdak, Mark, Chen, Yuanyuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7688577/
https://ncbi.nlm.nih.gov/pubmed/32536017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202000282R
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