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Structure and function in rhodopsin: Mass spectrometric identification of the abnormal intradiscal disulfide bond in misfolded retinitis pigmentosa mutants

Retinitis pigmentosa (RP) point mutations in both the intradiscal (ID) and transmembrane domains of rhodopsin cause partial or complete misfolding of rhodopsin, resulting in loss of 11-cis-retinal binding. Previous work has shown that misfolding is caused by the formation of a disulfide bond in the...

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Detalles Bibliográficos
Main Authors: Hwa, John, Klein-Seetharaman, Judith, Khorana, H. Gobind
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC33130/
https://ncbi.nlm.nih.gov/pubmed/11320236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.061632798
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