Overexpression of Rhodopsin Alters the Structure and Photoresponse of Rod Photoreceptors

Rhodopsins are densely packed in rod outer-segment membranes to maximize photon absorption, but this arrangement interferes with transducin activation by restricting the mobility of both proteins. We attempted to explore this phenomenon in transgenic mice that overexpressed rhodopsin in their rods....

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Detalhes bibliográficos
Main Authors: Wen, Xiao-Hong, Shen, Lixin, Brush, Richard S., Michaud, Norman, Al-Ubaidi, Muayyad R., Gurevich, Vsevolod V., Hamm, Heidi E., Lem, Janis, DiBenedetto, Emmanuele, Anderson, Robert E., Makino, Clint L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2009
Assuntos:
Channels, Receptors, and Electrical Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716671/
https://ncbi.nlm.nih.gov/pubmed/19186132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.10.016
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