Overexpression of Rhodopsin Alters the Structure and Photoresponse of Rod Photoreceptors

Rhodopsins are densely packed in rod outer-segment membranes to maximize photon absorption, but this arrangement interferes with transducin activation by restricting the mobility of both proteins. We attempted to explore this phenomenon in transgenic mice that overexpressed rhodopsin in their rods....

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Bibliografiske detaljer
Main Authors: Wen, Xiao-Hong, Shen, Lixin, Brush, Richard S., Michaud, Norman, Al-Ubaidi, Muayyad R., Gurevich, Vsevolod V., Hamm, Heidi E., Lem, Janis, DiBenedetto, Emmanuele, Anderson, Robert E., Makino, Clint L.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2009
Fag:
Channels, Receptors, and Electrical Signaling
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716671/
https://ncbi.nlm.nih.gov/pubmed/19186132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.10.016
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