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The allosteric inhibition of glycine transporter 2 by bioactive lipid analgesics is controlled by penetration into a deep lipid cavity

The role of lipids in modulating membrane protein function is an emerging and rapidly growing area of research. The rational design of lipids that target membrane proteins for the treatment of pathological conditions is a novel extension in this field and provides a step forward in our understanding...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Wilson, Katie A., Mostyn, Shannon N., Frangos, Zachary J., Shimmon, Susan, Rawling, Tristan, Vandenberg, Robert J., O’Mara, Megan L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949037/
https://ncbi.nlm.nih.gov/pubmed/33450225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100282
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