Development of an N-acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain

Inhibitors that target the glycine transporter 2, GlyT2, show promise as analgesics but may be limited by their toxicity through complete or irreversible binding. Acyl-glycine inhibitors, however, are selective for GlyT2 and have been shown to provide analgesia in animal models of pain with minimal...

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Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Mostyn, Shannon N., Rawling, Tristan, Mohammadi, Sarasa, Shimmon, Susan, Frangos, Zachary J., Sarker, Subhodeep, Yousuf, Arsalan, Vetter, Irina, Ryan, Renae M., Christie, Macdonald J., Vandenberg, Robert J.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420064/
https://ncbi.nlm.nih.gov/pubmed/30714733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01775
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