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Structural comparisons of host and African swine fever virus dUTPases reveal new clues for inhibitor development

African swine fever, caused by the African swine fever virus (ASFV), is among the most significant swine diseases. There are currently no effective treatments against ASFV. ASFV contains a gene encoding a dUTPase (E165R), which is required for viral replication in swine macrophages, making it an att...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Biol Chem
Main Authors: Liang, Rui, Wang, Gang, Zhang, Ding, Ye, Gang, Li, Mengxia, Shi, Yuejun, Shi, Jiale, Chen, Huanchun, Peng, Guiqing
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2020
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948977/
https://ncbi.nlm.nih.gov/pubmed/33139328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014005
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