Structural comparisons of host and African swine fever virus dUTPases reveal new clues for inhibitor development

African swine fever, caused by the African swine fever virus (ASFV), is among the most significant swine diseases. There are currently no effective treatments against ASFV. ASFV contains a gene encoding a dUTPase (E165R), which is required for viral replication in swine macrophages, making it an att...

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Udgivet i:J Biol Chem
Main Authors: Liang, Rui, Wang, Gang, Zhang, Ding, Ye, Gang, Li, Mengxia, Shi, Yuejun, Shi, Jiale, Chen, Huanchun, Peng, Guiqing
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948977/
https://ncbi.nlm.nih.gov/pubmed/33139328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014005
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