Structural comparisons of host and African swine fever virus dUTPases reveal new clues for inhibitor development

African swine fever, caused by the African swine fever virus (ASFV), is among the most significant swine diseases. There are currently no effective treatments against ASFV. ASFV contains a gene encoding a dUTPase (E165R), which is required for viral replication in swine macrophages, making it an att...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Liang, Rui, Wang, Gang, Zhang, Ding, Ye, Gang, Li, Mengxia, Shi, Yuejun, Shi, Jiale, Chen, Huanchun, Peng, Guiqing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948977/
https://ncbi.nlm.nih.gov/pubmed/33139328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014005
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