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Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target
E165R, a highly specific dUTP nucleotidohydrolase (dUTPase) encoded by the African swine fever virus (ASFV) genome, is required for productive replication of ASFV in swine macrophages. Here, we solved the high-resolution crystal structures of E165R in its apo state and in complex with its product dU...
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| Gepubliceerd in: | mBio |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Microbiology
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6819664/ https://ncbi.nlm.nih.gov/pubmed/31662460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02483-19 |
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