Combinatorial CAR design improves target restriction

CAR T cells targeting the B lymphocyte antigen CD19 have led to remarkable clinical results in B cell leukemia and lymphoma but eliminate all B lineage cells, leading to increased susceptibility to severe infections. As malignant B cells will express either immunoglobulin (Ig) light chain κ or λ, we...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Köksal, Hakan, Dillard, Pierre, Juzeniene, Asta, Kvalheim, Gunnar, Smeland, Erlend B., Myklebust, June H., Inderberg, Else Marit, Wälchli, Sébastien
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948400/
https://ncbi.nlm.nih.gov/pubmed/33234592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016234
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