Targeting Telomerase with an HLA Class II-Restricted TCR for Cancer Immunotherapy

T cell receptor (TCR)-engineered T cell therapy is a promising cancer treatment approach. Human telomerase reverse transcriptase (hTERT) is overexpressed in the majority of tumors and a potential target for adoptive cell therapy. We isolated a novel hTERT-specific TCR sequence, named Radium-4, from...

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Pubblicato in:Mol Ther
Autori principali: Dillard, Pierre, Köksal, Hakan, Maggadottir, Solrun Melkorka, Winge-Main, Anna, Pollmann, Sylvie, Menard, Mathilde, Myhre, Marit Renée, Mælandsmo, Gunhild M., Flørenes, Vivi Ann, Gaudernack, Gustav, Kvalheim, Gunnar, Wälchli, Sébastien, Inderberg, Else Marit
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2021
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934585/
https://ncbi.nlm.nih.gov/pubmed/33212301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.11.019
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