Targeting KRAS mutations with HLA class II-restricted TCRs for the treatment of solid tumors

T-cell receptor (TCR) redirected T cells are considered as the next generation of care for the treatment of numerous solid tumors. KRAS mutations are driver neoantigens that are expressed in over 25% of all cancers and are thus regarded as ideal targets for Adoptive Cell Therapy (ACT). We have isola...

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Detalles Bibliográficos
Publicado en:Oncoimmunology
Main Authors: Dillard, Pierre, Casey, Nicholas, Pollmann, Sylvie, Vernhoff, Patrik, Gaudernack, Gustav, Kvalheim, Gunnar, Wälchli, Sébastien, Inderberg, Else Marit
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2021
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8216182/
https://ncbi.nlm.nih.gov/pubmed/34235003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2021.1936757
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