Population pharmacokinetics of the von Willebrand factor–factor VIII interaction in patients with von Willebrand disease

Recent studies have reported that patients with von Willebrand disease treated perioperatively with a von Willebrand factor (VWF)/factor VIII (FVIII) concentrate with a ratio of 2.4:1 (Humate P/Haemate P) often present with VWF and/or FVIII levels outside of prespecified target levels necessary to p...

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Vydáno v:Blood Adv
Hlavní autoři: Bukkems, Laura H., Heijdra, Jessica M., de Jager, Nico C. B., Hazendonk, Hendrika C. A. M., Fijnvandraat, Karin, Meijer, Karina, Eikenboom, Jeroen C. J., Laros-van Gorkom, Britta A. P., Leebeek, Frank W. G., Cnossen, Marjon H., Mathôt, Ron A. A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2021
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948283/
https://ncbi.nlm.nih.gov/pubmed/33683340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003891
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