Concerning P450 Evolution: Structural Analyses Support Bacterial Origin of Sterol 14α-Demethylases

Sterol biosynthesis, primarily associated with eukaryotic kingdoms of life, occurs as an abbreviated pathway in the bacterium Methylococcus capsulatus. Sterol 14α-demethylation is an essential step in this pathway and is catalyzed by cytochrome P450 51 (CYP51). In M. capsulatus, the enzyme consists...

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Bibliografiske detaljer
Udgivet i:Mol Biol Evol
Main Authors: Lamb, David C, Hargrove, Tatiana Y, Zhao, Bin, Wawrzak, Zdzislaw, Goldstone, Jared V, Nes, William David, Kelly, Steven L, Waterman, Michael R, Stegeman, John J, Lepesheva, Galina I
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Discoveries
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7947880/
https://ncbi.nlm.nih.gov/pubmed/33031537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msaa260
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