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Exploring Protein Space: From Hydrolase to Ligase by Substitution

The understanding of how proteins evolve to perform novel functions has long been sought by biologists. In this regard, two homologous bacterial enzymes, PafA and Dop, pose an insightful case study, as both rely on similar mechanistic properties, yet catalyze different reactions. PafA conjugates a s...

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Dettagli Bibliografici
Pubblicato in:Mol Biol Evol
Autori principali: Hecht, Nir, Monteil, Caroline L, Perrière, Guy, Vishkautzan, Marina, Gur, Eyal
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7947786/
https://ncbi.nlm.nih.gov/pubmed/32870983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msaa215
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