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Exploring Protein Space: From Hydrolase to Ligase by Substitution

The understanding of how proteins evolve to perform novel functions has long been sought by biologists. In this regard, two homologous bacterial enzymes, PafA and Dop, pose an insightful case study, as both rely on similar mechanistic properties, yet catalyze different reactions. PafA conjugates a s...

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Publicat a:Mol Biol Evol
Autors principals: Hecht, Nir, Monteil, Caroline L, Perrière, Guy, Vishkautzan, Marina, Gur, Eyal
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7947786/
https://ncbi.nlm.nih.gov/pubmed/32870983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msaa215
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