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Exploring Protein Space: From Hydrolase to Ligase by Substitution

The understanding of how proteins evolve to perform novel functions has long been sought by biologists. In this regard, two homologous bacterial enzymes, PafA and Dop, pose an insightful case study, as both rely on similar mechanistic properties, yet catalyze different reactions. PafA conjugates a s...

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Detalhes bibliográficos
Publicado no:Mol Biol Evol
Main Authors: Hecht, Nir, Monteil, Caroline L, Perrière, Guy, Vishkautzan, Marina, Gur, Eyal
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7947786/
https://ncbi.nlm.nih.gov/pubmed/32870983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msaa215
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