Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation

T effector cells promote inflammation in asthmatic patients and both Th2 and Th17 CD4 T cells have been implicated in severe forms of the disease. The metabolic phenotypes and dependencies of these cells, however, remain poorly understood in the regulation of airway inflammation. Here we show the br...

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Publicat a:J Immunol
Autors principals: Healey, Diana C. Contreras, Cephus, Jacqueline Y., Barone, Sierra M., Chowdhury, Nowrin U., Dahunsi, Debolanle O., Madden, Matthew Z., Ye, Xiang, Yu, Xuemei, Olszewski, Kellen, Young, Kirsten, Gerriets, Valerie A., Siska, Peter J., Dworski, Ryszard, Hemler, Jonathan, Locasale, Jason W., Poyurovsky, Masha V., Peebles, R. Stokes, Irish, Jonathan M., Newcomb, Dawn C., Rathmell, Jeffrey C.
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946768/
https://ncbi.nlm.nih.gov/pubmed/33558372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2001029
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