Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

Activated T cells differentiate into functional subsets with distinct metabolic programs. Glutaminase (GLS) converts glutamine to glutamate to support the tricarboxylic acid cycle and redox and epigenetic reactions. Here, we identify a key role for GLS in T cell activation and specification. Though...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell
Päätekijät: Johnson, Marc O., Wolf, Melissa M., Madden, Matthew Z., Andrejeva, Gabriela, Sugiura, Ayaka, Contreras, Diana C., Maseda, Damian, Liberti, Maria V., Paz, Katelyn, Kishton, Rigel J., Johnson, Matthew E., de Cubas, Aguirre A., Wu, Pingsheng, Li, Gongbo, Zhang, Yongliang, Newcomb, Dawn C., Wells, Andrew D., Restifo, Nicholas P., Rathmell, W. Kimryn, Locasale, Jason W., Davila, Marco L., Blazar, Bruce R., Rathmell, Jeffrey C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6361668/
https://ncbi.nlm.nih.gov/pubmed/30392958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.10.001
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