Proximal Tubule-Specific Deletion of AT(1a) Receptors in The Kidney Attenuates Circulating and Intratubular Angiotensin II-Induced Hypertension in PT-Agtr1a(−/−) Mice

The present study used a novel mouse model with proximal tubule-specific knockout of AT(1a) receptors in the kidney, PT-Agtr1a(−/−), to test the hypothesis that intratubular angiotensin II (Ang II) and AT(1a) receptors in the proximal tubules are required for maintaining normal blood pressure and th...

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Publié dans:Hypertension
Auteurs principaux: Li, Xiao Chun, Leite, Ana Paula Oliveira, Zheng, Xiaowen, Zhao, Chunling, Chen, Xu, Zhang, Liang, Zhou, Xinchun, Rubera, Isabelle, Tauc, Michel, Zhuo, Jia Long
Format: Artigo
Langue:Inglês
Publié: 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946728/
https://ncbi.nlm.nih.gov/pubmed/33641366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.120.16336
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