TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells

TDP-43 is extensively studied in neurons in physiological and pathological contexts. However, emerging evidence indicates that glial cells are also reliant on TDP-43 function. We demonstrate that deletion of TDP-43 in Schwann cells results in a dramatic delay in peripheral nerve conduction causing s...

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Vydáno v:eLife
Hlavní autoři: Chang, Kae-Jiun, Agrawal, Ira, Vainshtein, Anna, Ho, Wan Yun, Xin, Wendy, Tucker-Kellogg, Greg, Susuki, Keiichiro, Peles, Elior, Ling, Shuo-Chien, Chan, Jonah R
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2021
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946431/
https://ncbi.nlm.nih.gov/pubmed/33689679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64456
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