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Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation
Vitamin K antagonists are widely used anticoagulants targeting vitamin K epoxide reductases (VKOR), a unique family of integral membrane enzymes. To elucidate their catalytic cycle and inhibitory mechanism, here we report eleven x-ray crystal structures of human VKOR and a VKOR-like paralog with sub...
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| 出版年: | Science |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7946407/ https://ncbi.nlm.nih.gov/pubmed/33154105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abc5667 |
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