Loss of 5-Hydroxymethylcytosine as an Epigenetic Signature That Correlates With Poor Outcomes in Patients With Medulloblastoma

Medulloblastoma, as the most common malignant brain tumor in children, exhibits highly dysregulated DNA methylation. The novel epigenetic marker—5-hydroxymethylcytosine (5hmC) plays essential role in gene regulation during brain development and in brain tumors. However, the biological and clinical i...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Zhao, Fu, Zhang, Zhi-Wei, Zhang, Jing, Zhang, Shun, Zhang, Heng, Zhao, Chi, Chen, Yang, Luo, Lin, Tong, Wei-Min, Li, Chunde, Niu, Yamei, Liu, Pinan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7945595/
https://ncbi.nlm.nih.gov/pubmed/33718152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.603686
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