5-hydroxymethylcytosine loss is associated with poor prognosis for patients with WHO grade II diffuse astrocytomas

Currently, the reliable prognostic biomarkers for WHO grade II diffuse astrocytomas (DA) are still limited. We investigated the relations between the level of 5-Hydroxymethylcytosine (5hmC), an oxidated production of 5-methylcytosine (5mC) by the ten eleven translocated (TET) enzymes, and clinicopat...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Zhang, Feng, Liu, Yifan, Zhang, Zhiwen, Li, Jie, Wan, Yi, Zhang, Liying, Wang, Yangmei, Li, Xia, Xu, Yuqiao, Fu, Xin, Zhang, Xiumin, Zhang, Ming, Zhang, Zhekai, Zhang, Jing, Yan, Qingguo, Ye, Jing, Wang, Zhe, Chen, Charlie Degui, Lin, Wei, Li, Qing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749994/
https://ncbi.nlm.nih.gov/pubmed/26864347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20882
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