5-hydroxymethylcytosine loss is associated with poor prognosis for patients with WHO grade II diffuse astrocytomas

Currently, the reliable prognostic biomarkers for WHO grade II diffuse astrocytomas (DA) are still limited. We investigated the relations between the level of 5-Hydroxymethylcytosine (5hmC), an oxidated production of 5-methylcytosine (5mC) by the ten eleven translocated (TET) enzymes, and clinicopat...

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Published in:Sci Rep
Main Authors: Zhang, Feng, Liu, Yifan, Zhang, Zhiwen, Li, Jie, Wan, Yi, Zhang, Liying, Wang, Yangmei, Li, Xia, Xu, Yuqiao, Fu, Xin, Zhang, Xiumin, Zhang, Ming, Zhang, Zhekai, Zhang, Jing, Yan, Qingguo, Ye, Jing, Wang, Zhe, Chen, Charlie Degui, Lin, Wei, Li, Qing
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749994/
https://ncbi.nlm.nih.gov/pubmed/26864347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20882
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