Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer

PURPOSE: A major challenge in platinum-based cancer therapy is the clinical management of chemoresistant tumors, which have a largely unknown pathogenesis at the level of epigenetic regulation. EXPERIMENTAL DESIGN: We evaluated the potential of using global loss of 5-hydroxymethylcytosine (5-hmC) le...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Tucker, Douglass W., Getchell, Christopher R., McCarthy, Eric T., Ohman, Anders W., Sasamoto, Naoko, Xu, Shuyun, Ko, Joo Yeon, Gupta, Mamta, Shafrir, Amy, Medina, Jamie E., Lee, Jonathan J., MacDonald, Lauren A., Malik, Ammara, Hasselblatt, Kathleen T, Li, Wenjing, Zhang, Hong, Kaplan, Samuel J., Murphy, George F., Hirsch, Michelle S., Liu, Joyce F., Matulonis, Ursula A., Terry, Kathryn L., Lian, Christine G., Dinulescu, Daniela M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951622/
https://ncbi.nlm.nih.gov/pubmed/29263182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1958
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados