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The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer’s disease mutations

Plaques of the amyloid beta (Aß) peptide are a pathological hallmark of Alzheimer’s disease (AD), the most common form of dementia. Mutations in Aß also cause familial forms of AD (fAD). Here, we use deep mutational scanning to quantify the effects of >14,000 mutations on the aggregation of Aß. T...

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發表在:eLife
Main Authors: Seuma, Mireia, Faure, Andre J, Badia, Marta, Lehner, Ben, Bolognesi, Benedetta
格式: Artigo
語言:Inglês
出版: eLife Sciences Publications, Ltd 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7943193/
https://ncbi.nlm.nih.gov/pubmed/33522485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.63364
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