Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease

Retina and optic nerve are sites of extra-cerebral manifestations of Alzheimer’s Disease (AD). Amyloid-β (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau protein are detected in eyes from AD patients and transgenic animals in correlation with inflammation, reduction of synapses, v...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Latina, Valentina, Giacovazzo, Giacomo, Cordella, Federica, Balzamino, Bijorn Omar, Micera, Alessandra, Varano, Monica, Marchetti, Cristina, Malerba, Francesca, Florio, Rita, Ercole, Bruno Bruni, La Regina, Federico, Atlante, Anna, Coccurello, Roberto, Di Angelantonio, Silvia, Calissano, Pietro, Amadoro, Giuseppina
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7942014/
https://ncbi.nlm.nih.gov/pubmed/33750467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01138-1
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