Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer’s disease models

Clinical and neuropathological studies have shown that tau pathology better correlates with the severity of dementia than amyloid plaque burden, making tau an attractive target for the cure of Alzheimer’s disease. We have explored whether passive immunization with the 12A12 monoclonal antibody (26–3...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Brain Commun
Prif Awduron: Corsetti, Veronica, Borreca, Antonella, Latina, Valentina, Giacovazzo, Giacomo, Pignataro, Annabella, Krashia, Paraskevi, Natale, Francesca, Cocco, Sara, Rinaudo, Marco, Malerba, Francesca, Florio, Rita, Ciarapica, Roberta, Coccurello, Roberto, D’Amelio, Marcello, Ammassari-Teule, Martine, Grassi, Claudio, Calissano, Pietro, Amadoro, Giuseppina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2020
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425324/
https://ncbi.nlm.nih.gov/pubmed/32954296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/braincomms/fcaa039
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