Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer’s disease models

Clinical and neuropathological studies have shown that tau pathology better correlates with the severity of dementia than amyloid plaque burden, making tau an attractive target for the cure of Alzheimer’s disease. We have explored whether passive immunization with the 12A12 monoclonal antibody (26–3...

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Detalhes bibliográficos
Publicado no:Brain Commun
Main Authors: Corsetti, Veronica, Borreca, Antonella, Latina, Valentina, Giacovazzo, Giacomo, Pignataro, Annabella, Krashia, Paraskevi, Natale, Francesca, Cocco, Sara, Rinaudo, Marco, Malerba, Francesca, Florio, Rita, Ciarapica, Roberta, Coccurello, Roberto, D’Amelio, Marcello, Ammassari-Teule, Martine, Grassi, Claudio, Calissano, Pietro, Amadoro, Giuseppina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425324/
https://ncbi.nlm.nih.gov/pubmed/32954296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/braincomms/fcaa039
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