Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer’s disease and other tauopathies

The largest part of tau secreted from AD nerve terminals and released in cerebral spinal fluid (CSF) is C-terminally truncated, soluble and unaggregated supporting potential extracellular role(s) of NH(2) -derived fragments of protein on synaptic dysfunction underlying neurodegenerative tauopathies,...

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Pubblicato in:Oncotarget
Autori principali: Florenzano, Fulvio, Veronica, Corsetti, Ciasca, Gabriele, Ciotti, Maria Teresa, Pittaluga, Anna, Olivero, Gunedalina, Feligioni, Marco, Iannuzzi, Filomena, Latina, Valentina, Maria Sciacca, Michele Francesco, Sinopoli, Alessandro, Milardi, Danilo, Pappalardo, Giuseppe, Marco, De Spirito, Papi, Massimiliano, Atlante, Anna, Bobba, Antonella, Borreca, Antonella, Calissano, Pietro, Amadoro, Giuseppina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper: Gerotarget (Focus on Aging)
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630290/
https://ncbi.nlm.nih.gov/pubmed/29029390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17371
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