Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer’s disease and other tauopathies

The largest part of tau secreted from AD nerve terminals and released in cerebral spinal fluid (CSF) is C-terminally truncated, soluble and unaggregated supporting potential extracellular role(s) of NH(2) -derived fragments of protein on synaptic dysfunction underlying neurodegenerative tauopathies,...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Florenzano, Fulvio, Veronica, Corsetti, Ciasca, Gabriele, Ciotti, Maria Teresa, Pittaluga, Anna, Olivero, Gunedalina, Feligioni, Marco, Iannuzzi, Filomena, Latina, Valentina, Maria Sciacca, Michele Francesco, Sinopoli, Alessandro, Milardi, Danilo, Pappalardo, Giuseppe, Marco, De Spirito, Papi, Massimiliano, Atlante, Anna, Bobba, Antonella, Borreca, Antonella, Calissano, Pietro, Amadoro, Giuseppina
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2017
Teme:
Research Paper: Gerotarget (Focus on Aging)
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630290/
https://ncbi.nlm.nih.gov/pubmed/29029390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17371
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