Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer’s disease and other tauopathies

The largest part of tau secreted from AD nerve terminals and released in cerebral spinal fluid (CSF) is C-terminally truncated, soluble and unaggregated supporting potential extracellular role(s) of NH(2) -derived fragments of protein on synaptic dysfunction underlying neurodegenerative tauopathies,...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Florenzano, Fulvio, Veronica, Corsetti, Ciasca, Gabriele, Ciotti, Maria Teresa, Pittaluga, Anna, Olivero, Gunedalina, Feligioni, Marco, Iannuzzi, Filomena, Latina, Valentina, Maria Sciacca, Michele Francesco, Sinopoli, Alessandro, Milardi, Danilo, Pappalardo, Giuseppe, Marco, De Spirito, Papi, Massimiliano, Atlante, Anna, Bobba, Antonella, Borreca, Antonella, Calissano, Pietro, Amadoro, Giuseppina
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper: Gerotarget (Focus on Aging)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630290/
https://ncbi.nlm.nih.gov/pubmed/29029390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17371
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