The TSPO-specific Ligand PK11195 Protects Against LPS-Induced Cognitive Dysfunction by Inhibiting Cellular Autophagy

Perioperative neurocognitive disorders (PND) is a common postoperative neurological complication. Neuroinflammation is a major cause that leads to PND. Autophagy, an intracellular process of lysosomal degradation, plays an important role in the development and maintenance of nervous system. PK11195...

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Vydáno v:Front Pharmacol
Hlavní autoři: Lan, Nannan, Liu, Yongxin, Juan, Zhaodong, Zhang, Rui, Ma, Baoyu, Xie, Keliang, Sun, Lina, Feng, Hao, Sun, Meng, Liu, Jianfeng
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7941270/
https://ncbi.nlm.nih.gov/pubmed/33708121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.615543
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