TSPO Ligands PK11195 and Midazolam Reduce NLRP3 Inflammasome Activation and Proinflammatory Cytokine Release in BV-2 Cells

Neuroinflammation related to microglial activation plays an important role in neurodegenerative diseases. Translocator protein 18 kDa (TSPO), a biomarker of reactive gliosis, its ligands can reduce neuroinflammation and can be used to treat neurodegenerative diseases. Therefore, we explored whether...

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Vydáno v:Front Cell Neurosci
Hlavní autoři: Feng, Hao, Liu, Yongxin, Zhang, Rui, Liang, Yingxia, Sun, Lina, Lan, Nannan, Ma, Baoyu
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Cellular Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7759202/
https://ncbi.nlm.nih.gov/pubmed/33362467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2020.544431
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