Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins

Homologous recombination (HR) is an essential DNA double-strand break (DSB) repair mechanism, which is frequently inactivated in cancer. During HR, RAD51 forms nucleoprotein filaments on RPA-coated, resected DNA and catalyzes strand invasion into homologous duplex DNA. How RAD51 displaces RPA and as...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Belan, Ondrej, Barroso, Consuelo, Kaczmarczyk, Artur, Anand, Roopesh, Federico, Stefania, O’Reilly, Nicola, Newton, Matthew D., Maeots, Erik, Enchev, Radoslav I., Martinez-Perez, Enrique, Rueda, David S., Boulton, Simon J.
Format: Artigo
Language:Inglês
Published: Cell Press 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7941204/
https://ncbi.nlm.nih.gov/pubmed/33421363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.12.020
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