Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination

Repair of DNA double strand breaks by homologous recombination (HR) is initiated by Rad51 filament nucleation on single-stranded DNA (ssDNA), which catalyzes strand exchange with homologous duplex DNA. BRCA2 and the Rad51 paralogs are tumor suppressors and critical mediators of Rad51. To gain insigh...

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發表在:Cell
Main Authors: Taylor, Martin R.G., Špírek, Mário, Chaurasiya, Kathy R., Ward, Jordan D., Carzaniga, Raffaella, Yu, Xiong, Egelman, Edward H., Collinson, Lucy M., Rueda, David, Krejci, Lumir, Boulton, Simon J.
格式: Artigo
語言:Inglês
出版: Cell Press 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518479/
https://ncbi.nlm.nih.gov/pubmed/26186187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.06.015
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