Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein

Homologous recombination (HR) is essential for error-free repair of DNA double-strand breaks, perturbed replication forks (RFs), and post-replicative single-stranded DNA (ssDNA) gaps. To initiate HR, the recombination mediator and tumor suppressor protein BRCA2 facilitates nucleation of RAD51 on ssD...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Belan, Ondrej, Greenhough, Luke, Kuhlen, Lucas, Anand, Roopesh, Kaczmarczyk, Artur, Gruszka, Dominika T., Yardimci, Hasan, Zhang, Xiaodong, Rueda, David S., West, Stephen C., Boulton, Simon J.
Format: Artigo
Language:Inglês
Published: 2023
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615647/
https://ncbi.nlm.nih.gov/pubmed/37499663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2023.06.031
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