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Detection of pathological alpha-synuclein aggregates in human iPSC-derived neurons and tissue

The accumulation of proteins into insoluble aggregates is a common feature of several neurodegenerative diseases. Aggregated α-synuclein is a major component of Lewy bodies that pathologically define Parkinson's disease (PD). Here, we present methods for the detection of pathogenic conformation...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:STAR Protoc
Prif Awduron: Stojkovska, Iva, Mazzulli, Joseph R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7941090/
https://ncbi.nlm.nih.gov/pubmed/33733241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xpro.2021.100372
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