Alpha-synuclein induces the unfolded protein response in Parkinson’s disease SNCA triplication iPSC-derived neurons

The recent generation of induced pluripotent stem cells (iPSCs) from a patient with Parkinson’s disease (PD) resulting from triplication of the α-synuclein (SNCA) gene locus allows unprecedented opportunities to explore its contribution to the molecular pathogenesis of PD. We used the double-nicking...

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Publicado en:Hum Mol Genet
Main Authors: Heman-Ackah, Sabrina M, Manzano, Raquel, Hoozemans, Jeroen JM, Scheper, Wiep, Flynn, Rowan, Haerty, Wilfried, Cowley, Sally A, Bassett, Andrew R, Wood, Matthew JA
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886237/
https://ncbi.nlm.nih.gov/pubmed/28973645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx331
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