IL-10 Enhances Human Natural Killer Cell Effector Functions via Metabolic Reprogramming Regulated by mTORC1 Signaling

Cell metabolism plays a pivotal role in regulating the effector functions of immune cells. Stimulatory cytokines, such as interleukin (IL)-2 or IL-12 and IL-15, activate glycolysis and oxidative phosphorylation in natural killer (NK) cells to support their enhanced effector functions. IL-10, a pleio...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Wang, Zixi, Guan, Di, Huo, Jianxin, Biswas, Subhra K., Huang, Yuhan, Yang, Yuansheng, Xu, Shengli, Lam, Kong-Peng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7940510/
https://ncbi.nlm.nih.gov/pubmed/33708210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.619195
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