Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology

The tenovins are a frequently studied class of compounds capable of inhibiting sirtuin activity, which is thought to result in increased acetylation and protection of the tumor suppressor p53 from degradation. However, as we and other laboratories have shown previously, certain tenovins are also cap...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Ladds, Marcus J. G.W., Popova, Gergana, Pastor-Fernández, Andrés, Kannan, Srinivasaraghavan, van Leeuwen, Ingeborg M.M., Håkansson, Maria, Walse, Björn, Tholander, Fredrik, Bhatia, Ravi, Verma, Chandra S., Lane, David P., Laín, Sonia
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939445/
https://ncbi.nlm.nih.gov/pubmed/32900849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012056
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