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Exploiting polypharmacology for drug target deconvolution
Polypharmacology (action of drugs against multiple targets) represents a tempting avenue for new drug development; unfortunately, methods capable of exploiting the known polypharmacology of drugs for target deconvolution are lacking. Here, we present an ensemble approach using elastic net regulariza...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3977247/ https://ncbi.nlm.nih.gov/pubmed/24707051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403080111 |
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