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A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis
Wnt signaling plays a critical role in embryonic development, and genetic aberrations in this network have been broadly implicated in colorectal cancer. We find that the Wnt receptor Frizzled2 (Fzd2) and its ligands Wnt5a/b are elevated in metastatic liver, lung, colon, and breast cancer cell lines...
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| Udgivet i: | Cell |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4243058/ https://ncbi.nlm.nih.gov/pubmed/25417160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.10.032 |
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