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Identification of compounds that bind the centriolar protein SAS-6 and inhibit its oligomerization

Centrioles are key eukaryotic organelles that are responsible for the formation of cilia and flagella, and for organizing the microtubule network and the mitotic spindle in animals. Centriole assembly requires oligomerization of the essential protein spindle assembly abnormal 6 (SAS-6), which forms...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Busch, Julia M.C., Matsoukas, Minos-Timotheos, Musgaard, Maria, Spyroulias, Georgios A., Biggin, Philip C., Vakonakis, Ioannis
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939395/
https://ncbi.nlm.nih.gov/pubmed/32873708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014780
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