Identification of compounds that bind the centriolar protein SAS-6 and inhibit its oligomerization

Centrioles are key eukaryotic organelles that are responsible for the formation of cilia and flagella, and for organizing the microtubule network and the mitotic spindle in animals. Centriole assembly requires oligomerization of the essential protein spindle assembly abnormal 6 (SAS-6), which forms...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Busch, Julia M.C., Matsoukas, Minos-Timotheos, Musgaard, Maria, Spyroulias, Georgios A., Biggin, Philip C., Vakonakis, Ioannis
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939395/
https://ncbi.nlm.nih.gov/pubmed/32873708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014780
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