In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1

Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Δ(1)-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H. Many cancers alter their proline metabolism by up-regulating the proline cycle and proline biosynthesi...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:J Biol Chem
Main Authors: Christensen, Emily M., Bogner, Alexandra N., Vandekeere, Anke, Tam, Gabriela S., Patel, Sagar M., Becker, Donald F., Fendt, Sarah-Maria, Tanner, John J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2021
Ábhair:
Protein Structure and Folding
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939384/
https://ncbi.nlm.nih.gov/pubmed/33109600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016106
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla