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The Proline Cycle As a Potential Cancer Therapy Target

Interest in how proline contributes to cancer biology is expanding because of the emerging role of a novel proline metabolic cycle in cancer cell survival, proliferation, and metastasis. Proline biosynthesis and degradation involve the shared intermediate Δ(1)-pyrroline-5-carboxylate (P5C), which fo...

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Detalles Bibliográficos
Publicado en:Biochemistry
Main Authors: Tanner, John J., Fendt, Sarah-Maria, Becker, Donald F.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026536/
https://ncbi.nlm.nih.gov/pubmed/29648801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00215
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