In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1

Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Δ(1)-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H. Many cancers alter their proline metabolism by up-regulating the proline cycle and proline biosynthesi...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Christensen, Emily M., Bogner, Alexandra N., Vandekeere, Anke, Tam, Gabriela S., Patel, Sagar M., Becker, Donald F., Fendt, Sarah-Maria, Tanner, John J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2021
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939384/
https://ncbi.nlm.nih.gov/pubmed/33109600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016106
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