Variants associated with HHIP expression have sex-differential effects on lung function

Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that...

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Publicado en:Wellcome Open Res
Autores principales: Fawcett, Katherine A., Obeidat, Ma'en, Melbourne, Carl, Shrine, Nick, Guyatt, Anna L., John, Catherine, Luan, Jian'an, Richmond, Anne, Moksnes, Marta R., Granell, Raquel, Weiss, Stefan, Imboden, Medea, May-Wilson, Sebastian, Hysi, Pirro, Boutin, Thibaud S., Portas, Laura, Flexeder, Claudia, Harris, Sarah E., Wang, Carol A., Lyytikäinen, Leo-Pekka, Palviainen, Teemu, Foong, Rachel E., Keidel, Dirk, Minelli, Cosetta, Langenberg, Claudia, Bossé, Yohan, Van den Berge, Maarten, Sin, Don D., Hao, Ke, Campbell, Archie, Porteous, David, Padmanabhan, Sandosh, Smith, Blair H., Evans, David M., Ring, Sue, Langhammer, Arnulf, Hveem, Kristian, Willer, Cristen, Ewert, Ralf, Stubbe, Beate, Pirastu, Nicola, Klaric, Lucija, Joshi, Peter K., Patasova, Karina, Massimo, Mangino, Polasek, Ozren, Starr, John M., Karrasch, Stefan, Strauch, Konstantin, Meitinger, Thomas, Rudan, Igor, Rantanen, Taina, Pietiläinen, Kirsi, Kähönen, Mika, Raitakari, Olli T., Hall, Graham L., Sly, Peter D., Pennell, Craig E., Kaprio, Jaakko, Lehtimäki, Terho, Vitart, Veronique, Deary, Ian J., Jarvis, Debbie, Wilson, James F., Spector, Tim, Probst-Hensch, Nicole, Wareham, Nicholas J., Völzke, Henry, Henderson, John, Strachan, David P., Brumpton, Ben M., Hayward, Caroline, Hall, Ian P., Tobin, Martin D., Wain, Louise V.
Formato: Artigo
Lenguaje:Inglês
Publicado: F1000 Research Limited 2021
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7938335/
https://ncbi.nlm.nih.gov/pubmed/33728380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/wellcomeopenres.15846.2
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