Variants associated with HHIP expression have sex-differential effects on lung function

Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that...

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Detalhes bibliográficos
Publicado no:Wellcome Open Res
Main Authors: Fawcett, Katherine A., Obeidat, Ma'en, Melbourne, Carl, Shrine, Nick, Guyatt, Anna L., John, Catherine, Luan, Jian'an, Richmond, Anne, Moksnes, Marta R., Granell, Raquel, Weiss, Stefan, Imboden, Medea, May-Wilson, Sebastian, Hysi, Pirro, Boutin, Thibaud S., Portas, Laura, Flexeder, Claudia, Harris, Sarah E., Wang, Carol A., Lyytikäinen, Leo-Pekka, Palviainen, Teemu, Foong, Rachel E., Keidel, Dirk, Minelli, Cosetta, Langenberg, Claudia, Bossé, Yohan, Van den Berge, Maarten, Sin, Don D., Hao, Ke, Campbell, Archie, Porteous, David, Padmanabhan, Sandosh, Smith, Blair H., Evans, David M., Ring, Sue, Langhammer, Arnulf, Hveem, Kristian, Willer, Cristen, Ewert, Ralf, Stubbe, Beate, Pirastu, Nicola, Klaric, Lucija, Joshi, Peter K., Patasova, Karina, Massimo, Mangino, Polasek, Ozren, Starr, John M., Karrasch, Stefan, Strauch, Konstantin, Meitinger, Thomas, Rudan, Igor, Rantanen, Taina, Pietiläinen, Kirsi, Kähönen, Mika, Raitakari, Olli T., Hall, Graham L., Sly, Peter D., Pennell, Craig E., Kaprio, Jaakko, Lehtimäki, Terho, Vitart, Veronique, Deary, Ian J., Jarvis, Debbie, Wilson, James F., Spector, Tim, Probst-Hensch, Nicole, Wareham, Nicholas J., Völzke, Henry, Henderson, John, Strachan, David P., Brumpton, Ben M., Hayward, Caroline, Hall, Ian P., Tobin, Martin D., Wain, Louise V.
Formato: Artigo
Idioma:Inglês
Publicado em: F1000 Research Limited 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7938335/
https://ncbi.nlm.nih.gov/pubmed/33728380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/wellcomeopenres.15846.2
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