Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’s disease

Genetic and genome-wide association studies suggest a central role for microglia in Alzheimer’s disease (AD). However, single-cell RNA sequencing (scRNA-seq) of microglia in mice, a key preclinical model, has shown mixed results regarding translatability to human studies. To address this, scRNA-seq...

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Detalles Bibliográficos
Publicado en:Cell Rep
Autores principales: Yang, Hongtian Stanley, Onos, Kristen D., Choi, Kwangbom, Keezer, Kelly J., Skelly, Daniel A., Carter, Gregory W., Howell, Gareth R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7937391/
https://ncbi.nlm.nih.gov/pubmed/33567283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108739
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